DNA pol ι polyclonal, anti-human
€470.00
In stock
SKU
AC-AP69560
Background:
Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
Other Names:
POLI; RAD30B; DNA polymerase iota; Eta2; RAD30 homolog B
Antigen Type: synthetic peptide
Antigen Type: POLI
Gene ID: 11201
Primary Accession: Q9UNA4
Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
Other Names:
POLI; RAD30B; DNA polymerase iota; Eta2; RAD30 homolog B
Antigen Type: synthetic peptide
Antigen Type: POLI
Gene ID: 11201
Primary Accession: Q9UNA4
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