PGLa Peptide

Protein Family: Receptors and Channels

Pathway and Disease: Infectious Diseases

Alternate Names: PYLa/PGLa; pgla-a; PGLa; PYLa; PGLa-H; pyla

Accession No.: Q99134

Description:
PGLa is an antimicrobial peptide from the magainin family found within the granular gland secretions of the skin of the Xenopus laevis frog. It displays a broad spectrum against Gram-positive and Gram-negative bacteria. PGLa peptide also displays antifungal activity against C. albicans. PGLa peptide corresponds to aa39-59 of PYLa/PGLa A precursor after cleavage into PYLa, PGLa and PGLa-H.

Format:
Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.

MW: 1968.5 g/mol

Sequence:
Frog: H-Gly-Met-Ala-Ser-Lys-Ala-Gly-Ala-Ile-Ala-Gly-Lys-Ile-Ala-Lys-Val-Ala-Leu-Lys-Ala-Leu-NH2 or H-GMASKAGAIAGKIAKVALKAL-NH2

Composition:
C88H162N26O22S

Purity:
> 95% by HPLC

Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.