PGR Polyclonal Antibody

Background:
PGR, also named as NR3C3 and PR, belongs to the nuclear hormone receptor family and NR3 subfamily. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation. The ER and PR status has been used as a predictor of breast carcinoma responsiveness to endocrine therapy and as a prognostic indicator for early recurrence.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Neuroscience, Signal Transduction

Synonyms:
NR3C3, Nuclear receptor subfamily 3 group C member 3, PGR, PR, PRA, PRB, PRGR, Progesterone receptor, Progestin receptor form A, Progestin receptor form B

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse Progesterone receptor

Swissprot: P06401,Q00175,Q63449

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Concentration: 1.32 mg/mL
Dilution: IHC 1:200-1:800

Storage:
Store at -20°C. Avoid freeze / thaw cycles.