PGRMC2 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS5853
Background:
PGRMC2 (progesterone receptor membrane component 2), also known as DG6 (steroid receptor protein DG6) or PMBP (progesterone membrane-binding protein), is a single pass membrane protein belonging to the cytochrome b5 family (MAPR (membrane associated progesterone receptor) subfamily). Expressed in sperm, PGRMC2 is believed to function as a steroid receptor and may participate in the progesterone-dependent sperm acrosome reaction. PGRMC2 shares approximately 50% overall sequence identity with its close relative PGRMC1. The loss of the gene encoding PGRMC2 is associated with metastasis in uterine endocervical adenocarcinomas, implicating a potential role of PGRMC2 in the suppression of metastasis of endocervical adenocarcinomas.
Alternative Name:
Membrane-associated progesterone receptor component 2, Progesterone membrane-binding protein, Steroid receptor protein DG6, DG6, PMBP
Application Dilution: WB: 1:500~1:1000, ICC: 1:50~1:200
Specificity: PGRMC2 polyclonal antibody detects endogenous levels of PGRMC2 protein.
Immunogen:
Synthetic peptide, corresponding to the 178-223 of Human PGRMC2.
MW: ~ 24 kDa
Swis Prot.: O15173
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
PGRMC2 (progesterone receptor membrane component 2), also known as DG6 (steroid receptor protein DG6) or PMBP (progesterone membrane-binding protein), is a single pass membrane protein belonging to the cytochrome b5 family (MAPR (membrane associated progesterone receptor) subfamily). Expressed in sperm, PGRMC2 is believed to function as a steroid receptor and may participate in the progesterone-dependent sperm acrosome reaction. PGRMC2 shares approximately 50% overall sequence identity with its close relative PGRMC1. The loss of the gene encoding PGRMC2 is associated with metastasis in uterine endocervical adenocarcinomas, implicating a potential role of PGRMC2 in the suppression of metastasis of endocervical adenocarcinomas.
Alternative Name:
Membrane-associated progesterone receptor component 2, Progesterone membrane-binding protein, Steroid receptor protein DG6, DG6, PMBP
Application Dilution: WB: 1:500~1:1000, ICC: 1:50~1:200
Specificity: PGRMC2 polyclonal antibody detects endogenous levels of PGRMC2 protein.
Immunogen:
Synthetic peptide, corresponding to the 178-223 of Human PGRMC2.
MW: ~ 24 kDa
Swis Prot.: O15173
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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