PGRN polyclonal, anti-human, mouse, rat

Protein Family: Cytokines

Pathway and Disease: Cancers, Cell Growth and Death, Neurodegenerative Disorders, Signal Transduction

Description:
Granulins are a family of secreted glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Progranulin (PGRN) is processed into granulin and then into a variety of active 6-kDa peptides (granulin A-G) that have possible cytokine-like activities with a role in inflammation, wound repair and tissue remodeling. Granulins are highly expressed in myelogenous leukemic cell lines of promonocytic, promyelocytic and proerythroid lineages. Defects in progranulin are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD), the second most common cause of dementia in people under the age of 65 years.

Alternate Names: Granulins, Proepithelin, PEPI, Acrogranin, Paragranulin, Granulin-1, Granulin-2, Granulin-3, Granulin-4, Granulin-5, Granulin-6, Granulin-7, Granulin G, Granulin F, Granulin B, Granulin A, Granulin C, Granulin D, Granulin E, GRN, Progranulin, PGRN

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P28799

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human progranulin (granulin-6).

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 0.1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.