PHB2 polyclonal antibody, anti-human, mouse, rat

Background:
developmental stage:Levels of expression in fibroblasts decrease heterogeneously during cellular aging.,Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.,induction:Expression increases approximately 3-fold upon entry into G1 phase compared to other phases of the cell cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol.,Belongs to the prohibitin family.,subcellular location:Also cytoplasmic and nuclear.,subunit:Interacts with PHB, ESR1, HDAC1 and HDAC5.,

Research Area: Epigenetics and nuclear signaling, Cell biology

Synonyms: Prohibitin-2 , B-cell receptor-associated protein BAP37, D-prohibitin, Repressor of estrogen receptor activity

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year