PHC3 polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS8250
Background:
Polycomb group (PcG) proteins assemble into multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes throughout development. PHC3 (Polyhomeotic-like protein 3), also known as Early development regulatory protein 3, is a 983 amino acid nuclear protein that is a component of the PcG multiprotein PRC1 complex. Specifically, the PcG PRC1 complex modifies histones, remodels chromatin and mediates monoubiquination of Histone H2A. Other constituent proteins involved in the PcG PRC1 complex are Mel-18, Bmi-1, M33, MPc2, MPc3, RING1, Ring1b, as well as several others. Loss of heterozygosity of the PHC3 gene was observed in human osteosarcoma tumors, suggesting that loss of PHC3 protein may contribute to tumorigenesis. There are six isoforms of PHC3 that are expressed as a result of alternative splicing events.
Alternative Name:
Polyhomeotic-like protein 3, Early development regulatory protein 3, Homolog of polyhomeotic 3, hPH3, PHC3, EDR3, PH3
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: PHC3 polyclonal antibody detects endogenous levels of PHC3 protein.
Immunogen:
Recombinant full length Human PHC3.
MW: ~ 106 kDa
Swis Prot.: Q8NDX5
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Polycomb group (PcG) proteins assemble into multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes throughout development. PHC3 (Polyhomeotic-like protein 3), also known as Early development regulatory protein 3, is a 983 amino acid nuclear protein that is a component of the PcG multiprotein PRC1 complex. Specifically, the PcG PRC1 complex modifies histones, remodels chromatin and mediates monoubiquination of Histone H2A. Other constituent proteins involved in the PcG PRC1 complex are Mel-18, Bmi-1, M33, MPc2, MPc3, RING1, Ring1b, as well as several others. Loss of heterozygosity of the PHC3 gene was observed in human osteosarcoma tumors, suggesting that loss of PHC3 protein may contribute to tumorigenesis. There are six isoforms of PHC3 that are expressed as a result of alternative splicing events.
Alternative Name:
Polyhomeotic-like protein 3, Early development regulatory protein 3, Homolog of polyhomeotic 3, hPH3, PHC3, EDR3, PH3
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: PHC3 polyclonal antibody detects endogenous levels of PHC3 protein.
Immunogen:
Recombinant full length Human PHC3.
MW: ~ 106 kDa
Swis Prot.: Q8NDX5
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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