PHF10 polyclonal, anti-human, mouse, rat

Background:
Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

Alternative Name:
BAF45a, BAF45a, BRG1-associated factor 45a, FLJ10975, MGC111009, PHD finger protein 10, PHD finger protein 10, isoform a, PHD zinc finger protein XAP135, Phf10, PHF10, XAP135,

Application Dilution:
WB:1:500-1:1,000
IHC:1:50-1:200

Specificity: PHF10 polyclonal antibody detects endogenous levels of PHF10 protein.

Immunogen:
Recombinant protein

MW: 56 kDa

Swiss-Prot: Q8WUB8(Human) Q9D8M7(Mouse) Q4V7A6(Rat)

Purification & Purity:
Protein affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.