PHF17 polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS8143
Background:
Jade-1, also known as PHF17 (PHD finger protein 17), is an 842 amino acid protein that localizes to both the cytoplasm and the nucleus and contains two PHD-type zinc fingers. Expressed at high levels in kidney tissue and also present in heart, pancreas and liver, Jade-1 functions as a transcriptional coactivator that, via its PHD zinc fingers, promotes the TIP30-dependent acetylation of Histone H4. Additionally, Jade-1 is thought to promote apoptosis and is down-regulated in renal carcinoma cells, suggesting a possible role in tumor suppression. Three isoforms of Jade-1, two of which are designated JADE1L and JADE1S, are produced via alternative splicing events. The gene encoding Jade-1 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes.
Alternative Name:
Protein Jade-1, Jade family PHD finger protein 1, PHD finger protein 17, JADE1, KIAA1807, PHF17
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: PHF17 polyclonal antibody detects endogenous levels of PHF17 protein.
Immunogen:
Recombinant full length Human PHF17.
MW: ~ 96 kDa
Swis Prot.: Q6IE81
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Jade-1, also known as PHF17 (PHD finger protein 17), is an 842 amino acid protein that localizes to both the cytoplasm and the nucleus and contains two PHD-type zinc fingers. Expressed at high levels in kidney tissue and also present in heart, pancreas and liver, Jade-1 functions as a transcriptional coactivator that, via its PHD zinc fingers, promotes the TIP30-dependent acetylation of Histone H4. Additionally, Jade-1 is thought to promote apoptosis and is down-regulated in renal carcinoma cells, suggesting a possible role in tumor suppression. Three isoforms of Jade-1, two of which are designated JADE1L and JADE1S, are produced via alternative splicing events. The gene encoding Jade-1 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes.
Alternative Name:
Protein Jade-1, Jade family PHD finger protein 1, PHD finger protein 17, JADE1, KIAA1807, PHF17
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: PHF17 polyclonal antibody detects endogenous levels of PHF17 protein.
Immunogen:
Recombinant full length Human PHF17.
MW: ~ 96 kDa
Swis Prot.: Q6IE81
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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