PHF19 polyclonal, anti-human, mouse, rat

Background:
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36'(H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing.

Synonyms: MTF2L1, PCL3, TDRD19B

Cellular Location: Nucleus

Immunogen:
Recombinant protein of human PHF19

Gene Symbol: PHF19

Gene ID: 26147

Swiss prot: Q5T6S3

Calculated MW: 66kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200, IF 1:50-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.