PHKA1 Antibody (Center) Blocking peptide
€363.00
In stock
SKU
AC-BP12245c
Background:
Phosphorylase kinase is a polymer of 16 subunits, foureach of alpha, beta, gamma and delta. The alpha subunit includesthe skeletal muscle and hepatic isoforms, and the skeletal muscleisoform is encoded by this gene. The beta subunit is the same inboth the muscle and hepatic isoforms, and encoded by one gene. Thegamma subunit also includes the skeletal muscle and hepaticisoforms, which are encoded by two different genes. The deltasubunit is a calmodulin and can be encoded by three differentgenes. The gamma subunits contain the active site of the enzyme,whereas the alpha and beta subunits have regulatory functionscontrolled by phosphorylation. The delta subunit mediates thedependence of the enzyme on calcium concentration. Mutations inthis gene cause glycogen storage disease type 9D, also known asX-linked muscle glycogenosis. Alternatively spliced transcriptvariants encoding different isoforms have been identified in thisgene. A pseudogene has been found on chromosome 1.
Other Names:
Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform, Phosphorylase kinase alpha M subunit, PHKA1, PHKA
Gene Name: PHKA1
Gene ID: 5255
Primary Accession: P46020
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Phosphorylase kinase is a polymer of 16 subunits, foureach of alpha, beta, gamma and delta. The alpha subunit includesthe skeletal muscle and hepatic isoforms, and the skeletal muscleisoform is encoded by this gene. The beta subunit is the same inboth the muscle and hepatic isoforms, and encoded by one gene. Thegamma subunit also includes the skeletal muscle and hepaticisoforms, which are encoded by two different genes. The deltasubunit is a calmodulin and can be encoded by three differentgenes. The gamma subunits contain the active site of the enzyme,whereas the alpha and beta subunits have regulatory functionscontrolled by phosphorylation. The delta subunit mediates thedependence of the enzyme on calcium concentration. Mutations inthis gene cause glycogen storage disease type 9D, also known asX-linked muscle glycogenosis. Alternatively spliced transcriptvariants encoding different isoforms have been identified in thisgene. A pseudogene has been found on chromosome 1.
Other Names:
Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform, Phosphorylase kinase alpha M subunit, PHKA1, PHKA
Gene Name: PHKA1
Gene ID: 5255
Primary Accession: P46020
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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