PHLPP1 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60440
Background:
SCOP (Suprachiasmatic nucleus circadian oscillatory protein, PHLPP, PH domain and leucine rich repeat protein phosphatase, PLEKHE1) is a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Endogenous SCOP in human embryonic kidney cell lysates produces a major protein and minor protein. SCOP negatively regulates K-Ras signaling in membrane rafts and contributes to the regulation of the Ras-MAPK signaling pathway. Recombinant SCOP can dephosphorylate the hydrophobic motif of Akt1 (ser-473) in vitro, triggering apoptosis and suppressing tumor growth. SCOP levels appear lower in certain colon cancer and glioblastoma cell lines that show elevated Akt phosphorylation. Rat tissues that express SCOP include cerebrum, cerebellum, and testis.
Alternative Name:
PH domain leucine-rich repeat-containing protein phosphatase 1, Pleckstrin homology domain-containing family E member 1, PH domain-containing family E member 1, Suprachiasmatic nucleus circadian oscillatory protein, hSCOP, PHLPP1, KIAA0606, PHLPP, PLEKHE1, SCOP
Application Dilution: WB: 1:500~1:1000
Specificity: PHLPP1 polyclonal antibody detects endogenous levels of PHLPP1 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human PHLPP1.
MW: ~ 171 kDa
Swis Prot.: O60346
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
SCOP (Suprachiasmatic nucleus circadian oscillatory protein, PHLPP, PH domain and leucine rich repeat protein phosphatase, PLEKHE1) is a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Endogenous SCOP in human embryonic kidney cell lysates produces a major protein and minor protein. SCOP negatively regulates K-Ras signaling in membrane rafts and contributes to the regulation of the Ras-MAPK signaling pathway. Recombinant SCOP can dephosphorylate the hydrophobic motif of Akt1 (ser-473) in vitro, triggering apoptosis and suppressing tumor growth. SCOP levels appear lower in certain colon cancer and glioblastoma cell lines that show elevated Akt phosphorylation. Rat tissues that express SCOP include cerebrum, cerebellum, and testis.
Alternative Name:
PH domain leucine-rich repeat-containing protein phosphatase 1, Pleckstrin homology domain-containing family E member 1, PH domain-containing family E member 1, Suprachiasmatic nucleus circadian oscillatory protein, hSCOP, PHLPP1, KIAA0606, PHLPP, PLEKHE1, SCOP
Application Dilution: WB: 1:500~1:1000
Specificity: PHLPP1 polyclonal antibody detects endogenous levels of PHLPP1 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human PHLPP1.
MW: ~ 171 kDa
Swis Prot.: O60346
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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