Phospho-ACTH(S168) Antibody Blocking peptide
€363.00
In stock
SKU
AC-BP3738a
Background:
This gene encodes a polypeptide hormone precursor thatundergoes extensive, tissue-specific, post-translational processingvia cleavage by subtilisin-like enzymes known as prohormoneconvertases. There are eight potential cleavage sites within thepolypeptide precursor and, depending on tissue type and theavailable convertases, processing may yield as many as tenbiologically active peptides involved in diverse cellularfunctions. The encoded protein is synthesized mainly incorticotroph cells of the anterior pituitary where four cleavagesites are used; adrenocorticotrophin, essential for normalsteroidogenesis and the maintenance of normal adrenal weight, andlipotropin beta are the major end products. In other tissues,including the hypothalamus, placenta, and epithelium, all cleavagesites may be used, giving rise to peptides with roles in pain andenergy homeostasis, melanocyte stimulation, and immune modulation.These include several distinct melanotropins, lipotropins, andendorphins that are contained within the adrenocorticotrophin andbeta-lipotropin peptides. Mutations in this gene have beenassociated with early onset obesity, adrenal insufficiency, and redhair pigmentation. Alternatively spliced transcript variantsencoding the same protein have been described. [provided byRefSeq].
Other Names:
Pro-opiomelanocortin, POMC, Corticotropin-lipotropin, NPP, Melanotropin gamma, Gamma-MSH, Potential peptide, Corticotropin, Adrenocorticotropic hormone, ACTH, Melanotropin alpha, Alpha-MSH, Corticotropin-like intermediary peptide, CLIP, Lipotropin beta, Beta-LPH, Lipotropin gamma, Gamma-LPH, Melanotropin beta, Beta-MSH, Beta-endorphin, Met-enkephalin, POMC
Gene Name: POMC
Gene ID: 5443
Primary Accession: P01189
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a polypeptide hormone precursor thatundergoes extensive, tissue-specific, post-translational processingvia cleavage by subtilisin-like enzymes known as prohormoneconvertases. There are eight potential cleavage sites within thepolypeptide precursor and, depending on tissue type and theavailable convertases, processing may yield as many as tenbiologically active peptides involved in diverse cellularfunctions. The encoded protein is synthesized mainly incorticotroph cells of the anterior pituitary where four cleavagesites are used; adrenocorticotrophin, essential for normalsteroidogenesis and the maintenance of normal adrenal weight, andlipotropin beta are the major end products. In other tissues,including the hypothalamus, placenta, and epithelium, all cleavagesites may be used, giving rise to peptides with roles in pain andenergy homeostasis, melanocyte stimulation, and immune modulation.These include several distinct melanotropins, lipotropins, andendorphins that are contained within the adrenocorticotrophin andbeta-lipotropin peptides. Mutations in this gene have beenassociated with early onset obesity, adrenal insufficiency, and redhair pigmentation. Alternatively spliced transcript variantsencoding the same protein have been described. [provided byRefSeq].
Other Names:
Pro-opiomelanocortin, POMC, Corticotropin-lipotropin, NPP, Melanotropin gamma, Gamma-MSH, Potential peptide, Corticotropin, Adrenocorticotropic hormone, ACTH, Melanotropin alpha, Alpha-MSH, Corticotropin-like intermediary peptide, CLIP, Lipotropin beta, Beta-LPH, Lipotropin gamma, Gamma-LPH, Melanotropin beta, Beta-MSH, Beta-endorphin, Met-enkephalin, POMC
Gene Name: POMC
Gene ID: 5443
Primary Accession: P01189
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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