Phospho-ALK(Y1604) Blocking Peptide
€363.00
In stock
SKU
AC-BP3760a
Background:
The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK (leukocyte tyrosine kinase). ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.
Other Names:
ALK tyrosine kinase receptor, Anaplastic lymphoma kinase, CD246, ALK
Target/Specificity:
The synthetic peptide sequence is selected from aa 1599-1612 of HUMAN ALK
Gene Name: ALK {ECO:0000303|PubMed:9174053, ECO:0000312|HGNC:HGNC:427}
Gene ID: 238
Primary Accession: Q9UM73
Other Accession: NP_004295.2
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK (leukocyte tyrosine kinase). ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.
Other Names:
ALK tyrosine kinase receptor, Anaplastic lymphoma kinase, CD246, ALK
Target/Specificity:
The synthetic peptide sequence is selected from aa 1599-1612 of HUMAN ALK
Gene Name: ALK {ECO:0000303|PubMed:9174053, ECO:0000312|HGNC:HGNC:427}
Gene ID: 238
Primary Accession: Q9UM73
Other Accession: NP_004295.2
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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