Phospho-AMPKα1(S485) Polyclonal Antibody

Background:
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Research Area: Cancer, Cardiovascular, Metabolism, Neuroscience, Signal Transduction

Synonyms:
PRKAA1, AMPK, AMPKa1

Immunogen: A phospho specific peptide corresponding to residues surrounding S485 of human PRKAA1

Swissprot: Q13131
Gene ID: 5562

Calculated MW: 64 kDa/65 kDa
Observed MW: 56 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.