Phospho-ANTXR1(Y382) polyclonal, anti-human
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In stock
SKU
AC-AP3547a
Catalog Number: AC-AP3547a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB15324
Applications: DB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB15324
Applications: DB
Datasheet
Request Information
Background:
ANTXR1 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes.
Other Names:
Anthrax toxin receptor 1, Tumor endothelial marker 8, ANTXR1, ATR, TEM8
Target/Specificity:
This ANTXR1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y382 of human ANTXR1.
Antigen Type: Synthetic Peptide
Gene Name: ANTXR1 {ECO:0000303|PubMed:22912819, ECO:0000312|HGNC:HGNC:21014}
Gene ID: 84168
Primary Accession: Q9H6X2
NCBI Accession: NP_060623.2;NP_115584.1;NP_444262.1
Other Accession: Q6DFX2; P58335; Q0PMD2; Q9CZ52
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
ANTXR1 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes.
Other Names:
Anthrax toxin receptor 1, Tumor endothelial marker 8, ANTXR1, ATR, TEM8
Target/Specificity:
This ANTXR1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y382 of human ANTXR1.
Antigen Type: Synthetic Peptide
Gene Name: ANTXR1 {ECO:0000303|PubMed:22912819, ECO:0000312|HGNC:HGNC:21014}
Gene ID: 84168
Primary Accession: Q9H6X2
NCBI Accession: NP_060623.2;NP_115584.1;NP_444262.1
Other Accession: Q6DFX2; P58335; Q0PMD2; Q9CZ52
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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