Phospho-ATM (Ser1981) Polyclonal Antibody

Background:
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
A-T mutated, A-T mutated homolog, AT mutated, AT1, ATA, Ataxia telangiectasia mutated, Ataxia telangiectasia mutated gene, Ataxia telangiectasia mutated homolog (human), Ataxia telangiectasia mutated homolog, ATC, ATD, ATDC, ATE, ATM, ATM serine/threonine kinase, ATM, DKFZp781A0353, MGC74674, OTTHUMP00000232981, Serine protein kinase ATM, Serine-protein kinase ATM, Serine/threonine-protein kinase ATM, Tefu, TEL1, TEL1, telomere maintenance 1, homolog, TELO1, Telomere fusion protein

Immunogen: Synthesized peptide derived from human Atm around the phosphorylation site of Ser1981

Swissprot: Q13315
Observed MW: 350 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200, ELISA 1:5000-1:20000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-7129/sc-7128/sc-1213/sc-1214/sc-1212/sc-7230/sc-15392/sc-28881