Phospho-β-catenin(S33/S37/T41) Polyclonal Antibody

Background:
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.

Research Area: Cancer, Cardiovascular, Neuroscience, Signal Transduction, Stem Cells

Synonyms:
CTNNB, MRD19, armadillo, beta Catenin, CTNNB1

Immunogen: A synthetic phosphorylated peptide around S33 & T41 of human beta Catenin (NP_001091679).

Swissprot: P35222
Gene ID: 1499

Calculated MW: 9 kDa/85 kDa
Observed MW: 85 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.