Phospho-Btk(Y223) Polyclonal Antibody

Background:
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms.

Research Area: Cancer, Immunology, Signal Transduction

Synonyms:
AGMX1, AT, ATK, BPK, IMD1, PSCTK1, XLA, BTK

Immunogen: A synthetic phosphorylated peptide around Y223 of human Btk (NP_000052.1).

Swissprot: Q06187
Gene ID: 695

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "IF 1:20-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.