Phospho-CDK1(T14) Polyclonal Antibody

Background:
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Neuroscience

Synonyms:
CDK1, CDC2, CDC28A, P34CDC2

Immunogen: A synthetic phosphorylated peptide around T14 of human CDK1 (NP_001777.1).

Swissprot: P06493
Gene ID: 983

Calculated MW: 27 kDa/34 kDa
Observed MW: 34 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:1000 IF 1:50-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.