Phospho-CFL1(S3) Polyclonal Antibody

Background:
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.

Research Area: Cancer, Cardiovascular, Neuroscience, Signal Transduction

Synonyms:
CFL1, CFL, HEL-S-15, cofilin, cofilin-1

Immunogen: A phospho specific peptide corresponding to residues surrounding S3 of human CFL1

Swissprot: P23528
Gene ID: 1072

Calculated MW: 18 kDa
Observed MW: 18 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:100 IF 1:100-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.