Phospho-CREB1 (Ser133) Polyclonal Antibody

Background:
This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Immunology

Synonyms:
Active transcription factor CREB, cAMP response element binding protein 1, cAMP response element binding protein, cAMP responsive element binding protein 1, cAMP-responsive element-binding protein 1, CREB, CREB-1, CREB1, CREB1, Cyclic AMP-responsive element-binding protein 1, MGC9284, OTTHUMP00000163864, OTTHUMP00000163865, OTTHUMP00000206660, OTTHUMP00000206662, OTTHUMP00000206667, Transactivator protein

Immunogen: Synthesized peptide derived from human CREB-1 around the phosphorylation site of Ser133

Swissprot: P16220

Calculated MW: 37 kDa
Observed MW: 37 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:100-1:300, ELISA 1:5000-1:20000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.