Phospho-CRK(S41) polyclonal, anti-human
€0.00
In stock
SKU
AC-AP3304a
Catalog Number: AC-AP3304a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB17175
Applications: DB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB17175
Applications: DB
Datasheet
Request Information
Background:
CRK is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. It has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation.
Other Names:
Adapter molecule crk, Proto-oncogene c-Crk, p38, CRK
Target/Specificity:
This CRK Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S41 of human CRK.
Antigen Type: Synthetic Peptide
Gene Name: CRK
Gene ID: 1398
Primary Accession: P46108
NCBI Accession: NP_005197.3;NP_058431.2
Other Accession: Q63768; Q64010; Q96GA9
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
CRK is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. It has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation.
Other Names:
Adapter molecule crk, Proto-oncogene c-Crk, p38, CRK
Target/Specificity:
This CRK Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S41 of human CRK.
Antigen Type: Synthetic Peptide
Gene Name: CRK
Gene ID: 1398
Primary Accession: P46108
NCBI Accession: NP_005197.3;NP_058431.2
Other Accession: Q63768; Q64010; Q96GA9
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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