Phospho-CrkII (Tyr221) monoclonal, anti-human
€455.00
In stock
SKU
AC-ABO13179
Catalog Number: AC-ABO13179
Size: 100 µl
Isotype: Rabbit IgG
Applications: WB, IF, ICC
Datasheet
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Size: 100 µl
Isotype: Rabbit IgG
Applications: WB, IF, ICC
Datasheet
Request Information
Description: Anti-Phospho-CrkII (Tyr221) Rabbit Monoclonal Antibody . Tested in WB, ICC/IF applications. This antibody reacts with Human.
Protein Function:
The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling..
Other Names: Adapter molecule crk, Proto-oncogene c-Crk, p38, CRK
Clone Name(s):
Clone: FDE-3
Subcellular Localization: Cytoplasm. Cell membrane. Translocated to the plasma membrane upon cell adhesion..
Gene ID: 1398
Immunogen: A synthesized peptide derived from human Phospho-CrkII (Tyr221)
Calculated MW: 33831
Purification: Affinity-chromatography
Format: Liquid
Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Protein Function:
The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling..
Other Names: Adapter molecule crk, Proto-oncogene c-Crk, p38, CRK
Clone Name(s):
Clone: FDE-3
Subcellular Localization: Cytoplasm. Cell membrane. Translocated to the plasma membrane upon cell adhesion..
Gene ID: 1398
Immunogen: A synthesized peptide derived from human Phospho-CrkII (Tyr221)
Calculated MW: 33831
Purification: Affinity-chromatography
Format: Liquid
Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
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