Phospho-EIF4EBP1(S111) Antibody Blocking peptide
€363.00
In stock
SKU
AC-BP3473a
Background:
EIF4EBP1 is a member of a family of translation repressor proteins. This protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of EIF4EBP1 with eIF4E inhibits complex assembly and represses translation. EIF4EBP1 is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
Other Names:
Eukaryotic translation initiation factor 4E-binding protein 1, 4E-BP1, eIF4E-binding protein 1, Phosphorylated heat- and acid-stable protein regulated by insulin 1, PHAS-I, EIF4EBP1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP3473a was selected from the region of human Phospho-EIF4EBP1-S111. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: EIF4EBP1
Gene ID: 1978
Primary Accession: Q13541
Other Accession: NP_004086
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
EIF4EBP1 is a member of a family of translation repressor proteins. This protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of EIF4EBP1 with eIF4E inhibits complex assembly and represses translation. EIF4EBP1 is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
Other Names:
Eukaryotic translation initiation factor 4E-binding protein 1, 4E-BP1, eIF4E-binding protein 1, Phosphorylated heat- and acid-stable protein regulated by insulin 1, PHAS-I, EIF4EBP1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP3473a was selected from the region of human Phospho-EIF4EBP1-S111. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: EIF4EBP1
Gene ID: 1978
Primary Accession: Q13541
Other Accession: NP_004086
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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