Phospho-EIF4EBP1(T36) Polyclonal Antibody

Background:
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Metabolism

Synonyms:
4E-BP1, 4EBP1, BP-1, PHAS-I, EIF4EBP1

Immunogen: A phospho specific peptide corresponding to residues surrounding T36 of human EIF4EBP1

Swissprot: Q13541
Gene ID: 1978

Calculated MW: 12 kDa
Observed MW: 20 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.