Phospho-ESPL1(S1126) Polyclonal Antibody

Background:
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 or STAG2 in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 by ESPL1, or separase, which initiates the final separation of sister chromatids.

Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling

Synonyms:
ESPL1, ESP1, SEPA, separin

Immunogen: A synthetic phosphorylated peptide around S1126 of human ESPL1 (NP_036423.4).

Swissprot: Q14674
Gene ID: 9700

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "IF 1:20-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.