Phospho-FLT3(Y589/591) Polyclonal Antibody

Background:
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Research Area: Immunology, Signal Transduction

Synonyms:
FLT3, CD135, FLK-2, FLK2, STK1

Immunogen: A synthetic phosphorylated peptide around Y589 & Y591 of human FLT3 (NP_004110.2).

Swissprot: P36888
Gene ID: 2322

Calculated MW: 108 kDa/112 kDa
Observed MW: 113 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.