Phospho-Glucocorticoid Receptor (Ser211) Polyclonal Antibody

Background:
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction

Synonyms:
GCCR, GCR, GCR, GCRST, glucocorticoid nuclear receptor variant 1, Glucocorticoid receptor, GR, GRL, Grl1, nr3c1, Nuclear receptor subfamily 3 group C member 1, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

Immunogen: Synthesized peptide derived from human GR around the phosphorylation site of Ser211

Swissprot: P04150

Calculated MW: 86 kDa
Observed MW: 95 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.