Phospho-GRIN2B(Y1474) Polyclonal Antibody

Background:
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.

Research Area: Cancer, Neuroscience

Synonyms:
GRIN2B, EIEE27, GluN2B, MRD6, NMDAR2B, NR2B, hNR3

Immunogen: A phospho specific peptide corresponding to residues surrounding Y1474 of human GRIN2B

Swissprot: Q13224
Gene ID: 2904

Calculated MW: 166 kDa
Observed MW: 200 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.