Phospho-HDAC5(S498) Polyclonal Antibody

Background:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.

Research Area: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Stem Cells

Synonyms:
HDAC5, HD5, NY-CO-9

Immunogen: A phospho specific peptide corresponding to residues surrounding S498 of human HDAC5

Swissprot: Q9UQL6
Gene ID: 10014

Calculated MW: 112 kDa/121 kDa/122 kDa
Observed MW: 140 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.