Phospho-HDAC5 (Ser498) Polyclonal Antibody

Background:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors.

Research Area: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Stem Cells

Synonyms:
Antigen NY CO 9, Antigen NY-CO-9, HD5, HDAC 5, HDAC5, HDAC5, Histone deacetylase 5, NY CO 9

Immunogen: Synthesized peptide derived from human HDAC5 around the phosphorylation site of Ser498

Swissprot: Q9UQL6

Calculated MW: 122 kDa
Observed MW: 122 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:20000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-5250/sc-11419/sc-5252