Phospho-HDAC6 (Ser22) Polyclonal Antibody

Background:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Stem Cells

Synonyms:
CPBHM, FLJ16239, HD 6, HD6, HDAC 6, HDAC6, HDAC6, Histone deacetylase 6 (HD6), Histone deacetylase 6, JM 21, JM21, KIAA0901, OTTHUMP00000032398, OTTHUMP00000197663, PPP1R90, Protein phosphatase 1 regulatory subunit 90

Immunogen: Synthesized peptide derived from human HDAC6 around the phosphorylation site of Ser22

Swissprot: Q9UBN7

Calculated MW: 131 kDa
Observed MW: 131 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-5255/sc-5258/sc-11420