Phospho-IGF1R(Y1161) Polyclonal Antibody

Background:
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Research Area: Cancer, Developmental Biology, Signal Transduction

Synonyms:
IGF1R, CD221, IGFIR, IGFR, JTK13

Immunogen: A phospho specific peptide corresponding to residues surrounding Y1161 of human IGF1R

Swissprot: P08069
Gene ID: 3480

Calculated MW: 154 kDa
Observed MW: 95 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:100 IF 1:100-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.