Phospho-INSR(Y1361) polyclonal, anti-human
€0.00
In stock
SKU
AC-AP3134a
Catalog Number: AC-AP3134a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB7155
Applications: WB, IHC-P, DB
Datasheet
Request Information
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB7155
Applications: WB, IHC-P, DB
Datasheet
Request Information
Background:
After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake, thereby mediating the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). This protein can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1.
Other Names:
Insulin receptor, IR, CD220, Insulin receptor subunit alpha, Insulin receptor subunit beta, INSR
Target/Specificity:
This INSR Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1361 of human INSR.
Antigen Type: Synthetic Peptide
Gene Name: INSR
Gene ID: 3643
Primary Accession: P06213
NCBI Accession: NP_000199.2;NP_001073285.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake, thereby mediating the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). This protein can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1.
Other Names:
Insulin receptor, IR, CD220, Insulin receptor subunit alpha, Insulin receptor subunit beta, INSR
Target/Specificity:
This INSR Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1361 of human INSR.
Antigen Type: Synthetic Peptide
Gene Name: INSR
Gene ID: 3643
Primary Accession: P06213
NCBI Accession: NP_000199.2;NP_001073285.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
|---|
Write Your Own Review