Phospho-IRAK1(S376) Antibody Blocking peptide
€363.00
In stock
SKU
AC-BP3139a
Background:
IRAK1 binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. Isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for IL-1 signaling. Once phosphorylated, IRAK1 recruits the adapter protein PELI1. This protein is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B.
Other Names:
Interleukin-1 receptor-associated kinase 1, IRAK-1, IRAK1, IRAK
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP3139a was selected from the region of human Phospho-IRAK1-S376. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: IRAK1 (HGNC:6112)
Gene ID: 3654
Primary Accession: P51617
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
IRAK1 binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. Isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for IL-1 signaling. Once phosphorylated, IRAK1 recruits the adapter protein PELI1. This protein is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B.
Other Names:
Interleukin-1 receptor-associated kinase 1, IRAK-1, IRAK1, IRAK
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP3139a was selected from the region of human Phospho-IRAK1-S376. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: IRAK1 (HGNC:6112)
Gene ID: 3654
Primary Accession: P51617
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
| Is Featured? | No |
|---|
Write Your Own Review