Phospho-IRE1 (S724) ERN1 monoclonal, anti-human
€455.00
In stock
SKU
AC-ABO13130
Catalog Number: AC-ABO13130
Size: 100 µl
Isotype: Rabbit IgG
Applications: WB
Datasheet
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Size: 100 µl
Isotype: Rabbit IgG
Applications: WB
Datasheet
Request Information
Description: Anti-Phospho-IRE1 (S724) ERN1 Rabbit Monoclonal Antibody . Tested in WB application. This antibody reacts with Human.
Protein Function:
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis..
Other Names: Serine/threonine-protein kinase/endoribonuclease IRE1, Endoplasmic reticulum-to-nucleus signaling 1, Inositol-requiring protein 1, hIRE1p, Ire1-alpha, IRE1a, Serine/threonine-protein kinase, 2.7.11.1, Endoribonuclease, 3.1.26.-, ERN1 (HGNC:3449)
Clone Name(s):
Clone: EGH-5
Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type I membrane protein.
Tissue Specificity: Ubiquitously expressed. High levels observed in pancreatic tissue..
Gene ID: 2081
Immunogen: A synthesized peptide derived from human Phospho-IRE1 (S724)
Calculated MW: 109735
Purification: Affinity-chromatography
Format: Liquid
Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Protein Function:
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis..
Other Names: Serine/threonine-protein kinase/endoribonuclease IRE1, Endoplasmic reticulum-to-nucleus signaling 1, Inositol-requiring protein 1, hIRE1p, Ire1-alpha, IRE1a, Serine/threonine-protein kinase, 2.7.11.1, Endoribonuclease, 3.1.26.-, ERN1 (HGNC:3449)
Clone Name(s):
Clone: EGH-5
Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type I membrane protein.
Tissue Specificity: Ubiquitously expressed. High levels observed in pancreatic tissue..
Gene ID: 2081
Immunogen: A synthesized peptide derived from human Phospho-IRE1 (S724)
Calculated MW: 109735
Purification: Affinity-chromatography
Format: Liquid
Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
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