Phospho-IRF3(S396) Polyclonal Antibody

Background:
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Immunology

Synonyms:
IIAE7, IRF3

Immunogen: A phospho specific peptide corresponding to residues surrounding S396 of human IRF3

Swissprot: Q14653
Gene ID: 3661

Calculated MW: 12 kDa/16 kDa/33 kDa/47 kDa/49 kDa
Observed MW: 55 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.