Phospho-IRS1 (Tyr896) Polyclonal Antibody

Background:
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.

Research Area: Cancer, Cardiovascular, Metabolism, Neuroscience, Signal Transduction, Tags and Cell Markers

Synonyms:
HIRS 1, HIRS1, Insulin receptor substrate 1, IRS 1, IRS-1, IRS1, IRS1, OTTHUMP00000164234

Immunogen: Synthesized peptide derived from human IRS-1 around the phosphorylation site of Tyr896

Swissprot: P35568

Calculated MW: 132 kDa
Observed MW: 180 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000, ELISA 1:40000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-560/sc-7200