Phospho-JAK2/3 (Tyr966/939) rabbit polyclonal, anti-human, mouse, rat

Backgroud: Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2.

Synonyms: Tyrosine-protein kinase JAK2/JAK3 (EC 2.7.10.2, Janus kinase 2/Janus kinase 3, JAK-2/JAK-3)

Gene Name: JAK2/JAK3

Gene ID: 3717/3718

SwissProt ID: O60674/P52333

Purification: Affinity Purified

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.