Phospho-JAK3 (Tyr785) Polyclonal Antibody

Background:
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).

Research Area: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction

Synonyms:
EC 2.7.10.2, JAK 3, JAK L, JAK-3, Jak3, JAK3 HUMAN, JAK3, JAKL, Janus kinase 3 (a protein tyrosine kinase, leukocyte), Janus kinase 3, Janus Kinase3, L JAK, L-JAK, Leukocyte janus kinase, LJAK, Protein tyrosine kinase leukocyte, Tyrosine protein kinase JAK3, Tyrosine-protein kinase JAK3

Immunogen: Synthesized peptide derived from human JAK3 around the phosphorylation site of Tyr785

Swissprot: P52333

Calculated MW: 125 kDa
Observed MW: 125 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-34481/sc-34482/sc-1078/sc-1080/sc-513