Phospho-Jak3(Y980/981) Polyclonal Antibody

Background:
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).

Research Area: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction

Synonyms:
JAK3, JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK

Immunogen: A synthetic phosphorylated peptide around Y980 of human Jak3 (NP_000206.2).

Swissprot: P52333
Gene ID: 3718

Calculated MW: 68 kDa/121 kDa/125 kDa
Observed MW: 110 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.