Phospho-JKK1/SEK1/MKK4 polyclonal, anti-human, mouse, rat antibody
€355.00
In stock
SKU
AC-ABV10348-100
Catalog Number: AC-ABV10348-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
Request Information
Background:
SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflammatory cytokines. Activation of SEK1 occurs thro µgh phosphorylation of serine and threonine residues at positions 257 and 261, respectively, by MEKK. Like MEK, SEK is a dual-specificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop. Phosphorylation by Akt at Ser80 inhibits SEK1 and suppresses the stress-activated signal transduction.
Other Names:
MAP2K4, SERK1, MAPKKA, JNKK1, PRKMK4, MEK4
Primary Accession: P45985
Gene Name: MAP2K4
Gene ID: 6416
Concentration (mg/ml): 0.5 mg/ml
SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflammatory cytokines. Activation of SEK1 occurs thro µgh phosphorylation of serine and threonine residues at positions 257 and 261, respectively, by MEKK. Like MEK, SEK is a dual-specificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop. Phosphorylation by Akt at Ser80 inhibits SEK1 and suppresses the stress-activated signal transduction.
Other Names:
MAP2K4, SERK1, MAPKKA, JNKK1, PRKMK4, MEK4
Primary Accession: P45985
Gene Name: MAP2K4
Gene ID: 6416
Concentration (mg/ml): 0.5 mg/ml
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