Phospho-Leptin Receptor (Tyr1141) rabbit polyclonal, anti-human, mouse

Backgroud: On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity).

Synonyms: Leptin receptor, LEP-R, HuB219 OB receptor, OB-R, CD295, LEPR, DB, OBR

Gene Name: LEPR

Gene ID: 3953

SwissProt ID: P48357

Purification: Affinity Purified

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.