Phospho-LIMK1(Thr508)) polyclonal, anti-human

Background:
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. [provided by RefSeq].

Other Names:
LIM domain kinase 1, LIMK-1, LIMK1, LIMK

Target/Specificity:
This LIMK1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Thr508 of human LIMK1.

Antigen Type: Synthetic Peptide

Gene Name: LIMK1
Gene ID: 3984
Primary Accession: P53667
NCBI Accession: NP_001191355.1;NP_002305.1
Other Accession: NP_002305.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.