Phospho-LRRK2 (Ser395) rabbit polyclonal, anti-human, mouse

Backgroud: Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner.

Synonyms: AURA17, Dardarin antibody, , Leucine rich repeat kinase 2, LRRK 2 antibody, LRRK2, LRRK2_HUMAN, PARK 8, PARK8, RIPK7, ROCO 2, ROCO2

Gene Name: LRRK2

Gene ID: 120892

SwissProt ID: Q5S007

Purification: Affinity Chromatography

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.