Phospho-MAP2(S1539) polyclonal, anti-human
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In stock
SKU
AC-AP3668a
Catalog Number: AC-AP3668a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB15202
Applications: DB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB15202
Applications: DB
Datasheet
Request Information
Background:
MAP2 is the major microtubule associated protein of brain tissue. There are three forms of MAP2; two are similarily sized with apparent molecular weights of 280 kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 70 kDa (MAP2c). In the newborn rat brain, MAP2b and MAP2c are present, while MAP2a is absent. Between postnatal days 10 and 20, MAP2a appears. At the same time, the level of MAP2c drops by 10-fold. This change happens during the period when dendrite growth is completed and when neurons have reached their mature morphology. MAP2 is degraded by a Cathepsin D-like protease in the brain of aged rats. There is some indication that MAP2 is expressed at higher levels in some types of neurons than in other types. MAP2 is known to promote microtubule assembly and to form side-arms on microtubules. It also interacts with neurofilaments, actin, and other elements of the cytoskeleton.
Other Names:
Microtubule-associated protein 2, MAP-2, MAP2
Target/Specificity:
This MAP2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1539 of human MAP2.
Antigen Type: Synthetic Peptide
Gene Name: MAP2
Gene ID: 4133
Primary Accession: P11137
NCBI Accession: NP_001034627.1;NP_002365.3;NP_114033.2;NP_114035.2
Other Accession: P15146; P20357
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
MAP2 is the major microtubule associated protein of brain tissue. There are three forms of MAP2; two are similarily sized with apparent molecular weights of 280 kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 70 kDa (MAP2c). In the newborn rat brain, MAP2b and MAP2c are present, while MAP2a is absent. Between postnatal days 10 and 20, MAP2a appears. At the same time, the level of MAP2c drops by 10-fold. This change happens during the period when dendrite growth is completed and when neurons have reached their mature morphology. MAP2 is degraded by a Cathepsin D-like protease in the brain of aged rats. There is some indication that MAP2 is expressed at higher levels in some types of neurons than in other types. MAP2 is known to promote microtubule assembly and to form side-arms on microtubules. It also interacts with neurofilaments, actin, and other elements of the cytoskeleton.
Other Names:
Microtubule-associated protein 2, MAP-2, MAP2
Target/Specificity:
This MAP2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1539 of human MAP2.
Antigen Type: Synthetic Peptide
Gene Name: MAP2
Gene ID: 4133
Primary Accession: P11137
NCBI Accession: NP_001034627.1;NP_002365.3;NP_114033.2;NP_114035.2
Other Accession: P15146; P20357
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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