Phospho-MAP3K7-S412 polyclonal, anti-human, mouse, rat

Background:
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Synonyms: TAK1, MEKK7, TGF1a

Cellular Location: Cytoplasm Cell membrane

Immunogen:
Recombinant protein of human MAP3K7

Gene Symbol: MAP3K7

Gene ID: 6885

Swiss prot: O43318

Calculated MW: 67 kDa

Recommended dilution:
WB 1:500-2000, IHC 1:10-50,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.