Phospho-MAP3K7 (Thr187) Polyclonal Antibody

Background:
Component of a protein kinase signal transduction cascade. Mediator of TRAF6 and TGF-beta signal transduction. Activates IKBKB and MAPK8 in response to TRAF6 signaling. Stimulates NF-kappa-B activation and the p38 MAPK pathway. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK, but not that of NF-kappa-B.

Research Area: Cancer, Cardiovascular, Immunology, Signal Transduction

Synonyms:
M3K7, MAP3K 7, Map3k7, MEKK7, Mitogen activated protein kinase kinase kinase 7, Mitogen-activated protein kinase kinase kinase 7, TAK1, TGF beta activated kinase 1, TGF-beta-activated kinase 1, TGF1a, Transforming growth factor beta activated kinase 1, Transforming growth factor-beta-activated kinase 1

Immunogen: Synthesized peptide derived from human Tak1 around the phosphorylation site of Thr187

Swissprot: O43318

Calculated MW: 67 kDa
Observed MW: 60 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.