phospho-MLKL (S358) (6B4) Mouse mAb

Background:
Mixed lineage kinase domain-like protein (MLKL) is a pseudokinase that was identified as downstream target of RIP3 in the necroptosis pathway. During necroptosis RIP3 is phosphorylated at Ser227, which recruits MLKL and leads to its phosphorylation at Thr357 and Ser358.

Cellular localization: Cell membrane, Cytoplasm, Membrane

Specificity: Human

Alternative Names:
Mixed lineage kinase domain like protein, FLJ34389

Immunogen: Synthetic Peptide

Isotype: Mouse Monoclonal IgG1

Concentration: 1mg/ml

Recommended dilutions: IHC 1:100-200

Observed band: 54kDa

GeneID: 197259

Swiss-Prot No.: Q8NB16

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Store at -20°C. Avoid repeated freeze-thaw cycles.

NOTE: For Research Use Only